Monday, June 17, 2013

One step closer to a vaccine for a common respiratory disease

June 17, 2013 ? Young children and the elderly are especially susceptible to respiratory syncytial virus (RSV). The three-dimensional structure of respiratory syncytial virus has been solved by an international team from Finland and Switzerland.

RSV is a common cause of respiratory infection, but there is no vaccine available. It causes flu-like symptoms in healthy adults, but becomes life-threatening in young children and the elderly. It is estimated to cause over 100,000 deaths yearly worldwide.

The teams of Research Director Sarah Butcher (Institute of Biotechnology, University of Helsinki) and Professor Ari Helenius (ETH Zurich) have now solved the three-dimensional structure of RSV.

"The structural model helps us to understand how infectious viruses are formed. This information can be useful in the intelligent design of vaccines" said the researcher Lassi Liljeroos.

RSV is related to measles and mumps viruses. All three viruses parasitize human cells, stealing parts of the cell membrane to use as their own. In RSV the resulting virus membranes look likes tubes and spheres. We could show that the virus' matrix protein controls this shape.

"In addition, we observed that the fusion protein on the surface is in two different forms. The fusion protein is responsible for attaching the virus to human cells and invading them. This is an important finding because the fusion protein is the key molecule in developing therapeutic antibodies to the virus. "

This publication is part of Lassi Liljeroos' Ph. D. thesis where he has earlier studied measles virus. The research was supported by the Academy of Finland, the Sigrid Juselius Foundation, the Viikki Molecular Biosciences Graduate Programme, the European Research Council, and the European Molecular Biology Organisation.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/xXhMw39_Hr0/130617160750.htm

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David Wild: "Daddy's Song": A Father's Day Playlist With Daddy Issues

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Why do I get the feeling Kanye West is going to take his World's Greatest Dad mug way too seriously? My own great dad Stanley Wild's favorite song was not a Kanye classic, but rather "My Way" by Frank Sinatra. Today, if you're lucky enough to have a loving dad who's still around, then I say play your Old Man play whatever the hell he wants. Here's hoping my sons are reading this. But just in case it helps anyone out there, let's gather a playlist for all the dads out there. In that spirit, here are some of my own paternal favorites, and some suggestions from my extended family of followers at @Wildaboutmusic. As always, please add your own Father's Day favorites below.


DADDY'S SONG - Harry Nilsson
YOUR DADDY LOVES YOU - Gil Scott-Heron
INDEPENDENCE DAY - Bruce Springsteen
MY FATHER'S FATHER - The Civil Wars
STILL FIGHTING IT - Ben Folds
DADDY'S COME HOME - Gary U.S. Bonds
BEAUTIFUL BOY - John Lennon
I LOVE YOU DAD - James McCartney
IT'S FOR MY DAD - Nancy Sinatra
DADDY- Beyonce
PAPA WAS A ROLLING STONE - The Temptations
FATHER'S NAME WAS DAD - Fire
DADDY DON'T LIVE IN THAT NEW YORK CITY - Steely Dan
FOOTSTEPS OF OUR FATHERS - Pat Green
SOMETIMES YOU CAN'T MAKE IT ON YOUR OWN - U2 @Rusty_Olson
GONE DADDY GONE - Violent Femmes @taradublinrocks
FATHER & DAUGHTER - Paul Simon @sunnymorton
FATHER & SON - Cat Stevens @bpwesterhoof
I HATE YOU BIG DADDY - Dewey Cox
DADDY COULD SWEAR, I DECLARE - Gladys Knight & The Pips
DADDY'S HOME - The Jackson 5
MY FATHER'S GUN - Elton John
DADDY WHAT IF - Bobby Bare. Jr. with Isabella Bare
THE MAN WHO WAS THE CIRCUS - Shel @JaronLowe
BEING A DAD - Loudon Wainwright III
SATURDAY'S FATHER - Frankie Valli & The Four Seasons
DADDY'S HANDS - Holly Dunn @JoJo219
HE DIDN'T HAVE TO BE - Brad Paisley @LizaJaneToo
PERFECTLY GOOD GUITAR - John Hiatt @lowercasejames
LOVE WITHOUT END, AMEN - George Strait @clauds_garcia
FATHER OF MINE - Everclear @bradshaw1972
ANYTHING LIKE ME - Brad Paisley @2lazylabs
CATS IN THE CRADLE - Harry Chapin @treepaine
LANDSLIDE - Fleetwood Mac @TeacherTracy
SO LONG DAD - Harry Nilsson

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Follow David Wild on Twitter: www.twitter.com/Wildaboutmusic

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Source: http://www.huffingtonpost.com/david-wild/daddys-song-a-fathers-day_b_3448666.html

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Putin warns West: do not arm Syrian rebels who 'eat human organs'

LONDON (Reuters) - Russian President Vladimir Putin warned the West against arming Syrian rebels on Sunday, saying the foes of President Bashar al-Assad ate human organs and should not be supported.

In his first public comments since a decision by President Barack Obama's administration to arm rebels trying to overthrow Assad, Putin said Russia wanted to create the conditions for settling the two-year conflict.

"I think you will not deny that one does not really need to support the people who not only kill their enemies, but open up their bodies, eat their intestines, in front of the public and cameras," Putin said at a joint news conference in London with Prime Minister David Cameron.

"Are these the people you want to support? Is it them who you want to supply with weapons?"

(Reporting by Alexei Anishchuk and Guy Faulconbridge; editing by Maria Golovnina and Andrew Osborn)

Source: http://news.yahoo.com/putin-warns-west-not-arm-syrian-rebels-eat-170229225.html

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'Insolvent' Detroit moves closer to filing for bankruptcy | The Raw Story

By Reuters
Saturday, June 15, 2013 16:42 EDT

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By Bernie Woodall and Steve Neavling

DETROIT (Reuters) ? Detroit said on Friday it would stop making payments on some of its about $18.5 billion debt, which would put it in default, and the ?insolvent? city called on most of its creditors to accept pennies on the dollar to help it avoid the largest municipal bankruptcy filing in U.S. history.

In a forceful opening salvo of negotiations with debt holders, Detroit Emergency Manager Kevyn Orr announced a moratorium on some principal and interest payments, including one payment he said was due on Friday.

Under his proposal, Orr said unsecured debt holders would be paid less than 10 cents on the dollar, but some creditors would get a bit more based on city revenue. Some $11.5 billion of the debt is unsecured and $7 billion secured, according to figures presented by Orr.

Orr said secured creditors would get better treatment, although how much better was not specified.

?We may try to get a discount from them, but the reality is they are secured,? Orr said.

Secured credit means an asset is pledged to back the debt. For example, Detroit has secured its interest rate swap agreements with casino revenue.

He said the city would skip a $34 million payment due on Friday on $1.43 billion of pension certificates of participation, to allow the city to conserve cash needed to provide services to residents.

Fitch Ratings and Standard and Poor?s Ratings Services immediately downgraded Detroit?s rating to a level reserved for borrowers about to default.

?We expect default to be a virtual certainty,? S&P said in a statement accompanying its downgrade to CC from CCC-negative.

A trustee for the bond issue will have to certify that Detroit failed to make the payment on Friday, which would trigger a formal default.

Detroit?s crisis is being closely watched by U.S. debt markets. It did not immediately affect the $3.7 trillion U.S. municipal bond market, where prices ended higher on Friday.

Orr said he would meet with creditors over the next 30 days. Market participants said the outcome of those talks could lead to higher interest rates for the state of Michigan and even the broader market if Orr wins concessions from secured creditors.

?Financial mismanagement, a shrinking population, a dwindling tax base and other factors over the past 45 years have brought Detroit to the brink of financial and operational ruin,? Orr said in a statement.

Orr said the city was ?insolvent,? unable to pay its debts and needed shared sacrifices from everyone, including debt holders, to have any hope of a revival.

Insolvency and inability to pay debts are two tests a government must meet for a judge to accept a Chapter 9 municipal bankruptcy.

?It looks and feels like a pre-packaged bankruptcy plan,? said Richard Ciccarone, managing director at McDonnell Investment Management, in reaction to the proposal.

A pre-packaged bankruptcy is when an entity negotiates a deal with creditors and other interested parties in advance and presents that to a bankruptcy court judge.

Orr, a bankruptcy attorney brought in by the state of Michigan to clean up the city?s finances, repeated after the meeting that he sees a 50/50 chance of a bankruptcy filing.

It would be a first for a major U.S. city as New York, Philadelphia and Cleveland all avoided formal bankruptcy filings during their financial difficulties.

New York also declared a moratorium on some debt payments in the 1970s, but creditors were ultimately paid in full under a restructuring agreement, said Jim Spiotto, a municipal bankruptcy expert at law firm Chapman and Cutler in Chicago.

In addition to the financial details, the 134-page document presented on Friday describes collapsing city services, rising crime and falling tax receipts.

Detroit is the poorest large city in the United States, with more than a third of its residents living below the official government poverty line, while its population has shrunk to about 700,000 people.

The city has the highest violent crime rate of any major U.S. city, some 78,000 abandoned and blighted structures and 40 percent of street lights dark, the document said. Only about a third of the city?s ambulances were in service in the first quarter of 2013. Just 53 percent of owners paid their 2011 property taxes.

The document disclosed that Detroit could face unfunded pension liabilities, such as for retired police and fire workers, of $3.5 billion, up from the $644 million previously estimated.

Orr said unsecured creditors, including bondholders and pension funds, will receive a pro rata share of $2 billion of notes the city would issue and pay off as its financial circumstances improve.

An oversight board could be created for Detroit, similar to one set up after New York City?s financial difficulties in 1970s that would ensure reforms are sustained, Orr said. The New York board created in 1975 still exists, although it is largely symbolic.

City workers and retirees would also face changes to their pensions and health care coverage ?consistent with available funding.?

At the same time, Orr proposed investing $1.25 billion over the next 10 years to improve the city?s infrastructure, remove or repair crumbling houses and update computer systems.

Initial reaction from debt holders and labor unions was negative.

Emerging from the meeting, one bond holder who asked not to be identified, said of Orr?s proposal to pay them only pennies on the dollar: ?It?s just too much. It is an unprecedented amount to ask.?

In the past, bondholders have not lost the principal amount owed them as a result of the financial restructuring of major cities such as New York and Cleveland.

Much of Detroit?s debt is insured, giving bondholders protection against defaults. Two of the insurers, National Public Finance Guarantee Corp, a unit of MBIA and Assured Guaranty Ltd, confirmed they attended the meeting.

?In the event that debt service payments by the City of Detroit are interrupted, National will ensure that its policyholders receive all of their principal and interest payments on time and in full,? spokesman Kevin Brown said.

Leaders of some of Detroit?s 48 public sector unions were upset by Orr?s proposals, which included spinning off water and sewer services into an independent authority, as well as making the changes to pensions and health care coverage.

?When you?re backed into a corner, the only thing you can do is fight and the only way we can fight is to strike,? said Mike Mulholland, secretary and treasurer of AFSCME Local 207, the union that represents water and sewer workers.

(Additional reporting by Karen Pierog, Deepa Seetharaman, Joseph Lichterman, Tiziana Barghini, Tom Hals and Alison Griswold; Writing by Karen Pierog and Greg McCune; Editing by Chris Reese and Andre Grenon)

[Image: Detroit's emergency financial manager Kevyn Orr talks to members of the media outside the Detroit Newspapers building about the report he delivered to the State of Michigan about Detroit's finances, in Detroit, Michigan May 13, 2013. Reuters/Rebecca Cook]

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Source: http://www.rawstory.com/rs/2013/06/15/insolvent-detroit-moves-closer-to-filing-for-bankruptcy/

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Sunday, June 16, 2013

Obama honors first time WNBA champ Indiana Fever

(AP) ? President Barack Obama honored the WNBA champion Indiana Fever on Friday, calling the players role models for young athletes ? even those on his daughter Sasha's basketball team.

The team captured its first title last October, defeating the Minnesota Lynx 87-78 and bringing home Indiana's first basketball title since 1973.

Obama said the Fever's season was an inspiration for basketball fans everywhere, including his daughter, whose team he sometimes coaches.

He pointed out that the Fever came into the playoffs as underdogs and had lost to the Lynx during the regular season, then rallied to take the championship.

"For her to have wonderful role models like this who work hard and know how to play like a team, are incredibly poised, are competitors but also show good sportsmanship, that's the kind of models you want for your children," Obama said.

It was the team's second trip to the WNBA finals in the history of the franchise. The Fever lost its first shot at the title in 2009 to the Phoenix Mercury 94-86.

Last year's championship gave series MVP Tamika Catchings, 33, who scored 25 points during the final game of the season, the only title she was missing on her resume.

"At every single stage of your life as you continue to grow ... it's your dream to win a championship," said Catchings, who has three Olympic gold medals and a 1998 NCAA championship from her career at the University of Tennessee. "This tops everything you do."

Obama joked about playing basketball with his "good friend" Catchings.

"I've had the pleasure of being on the court, and she took it easy on me," he said laughing.

Catchings, who was born deaf, also assists first lady Michelle Obama with her anti-obesity campaign. She founded her own organization "Catch the Stars," which promotes literacy, fitness and mentoring.

Following the remarks, and a ceremonial presentation of an Indiana jersey, hat and basketball to President Obama, the team hosted a clinic for about 40 children on the White House basketball court.

The recognition comes during a tough time for the Fever. Their current record of 1-4 marks their worst start since 2001.

"It's a disappointing start," Catchings told reporters afterward. "Right now our backs are against the wall we've got a lot of players injured and a lot of players out, but it's a motivating factor being here and having this opportunity. We have to get refocused."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-06-14-Obama-Indiana%20Fever%201st%20Ld-Writethru/id-f37324b629bc4eb398a4eaf522cc3b5a

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Saturday, June 15, 2013

How Green Groups Make the EPA Issue New Rules

Environmental groups have a tough time getting Congress to do what they want. Case in point: In the early months of 2010, the Sierra Club, the Natural Resources Defense Council, and the Environmental Defense Fund waged an all-out campaign urging the Senate to pass a sweeping climate-change bill backed by President Obama and leaders in the Democratic-controlled Senate. The measure crashed and burned that summer.

But the green groups?and Obama?s top environmental officials?knew they could resort to a different tactic: lawsuits to compel executive action. Toward the end of George W. Bush?s administration, the three big environmental organizations and 11 states sued to force the Environmental Protection Agency to issue new regulations reining in carbon pollution from coal-fired power plants and oil refineries. The Bush EPA fought the suit, but the Obama EPA, full of top officials who had worked in these very nonprofits, took a different tack. By December 2010, after the failure of the climate-change legislation, Obama?s first-term EPA administrator, Lisa Jackson, settled the lawsuit?on the advocates? terms. The settlement obliged the agency to begin regulating carbon pollution from coal plants and oil refineries, an outcome with profound environmental and economic implications. And in April 2012, EPA proposed a historic new rule to regulate global-warming pollution from coal plants. As Obama?s second term unfolds, the agency is expected to finalize more rules that, thanks to lawsuits, will give the green groups what they want.

The climate-change settlement is just one in a series of recent so-called sue-and-settle agreements since Obama took office. Between 2009 and 2012, EPA has settled at least 60 lawsuits from outside groups, leading to dozens of new environmental regulations. A 2010 deal in another Sierra Club lawsuit led to a 2012 regulation on mercury emissions from coal plants. A 2009 settlement with environmentalists led to a 2012 regulation governing pollution from cement manufacturers. While EPA could fight the suits, they often line up with the administration?s agenda?to fight climate change and promote clean-air laws?so why bother? In many cases, the federal government, as the loser in the legal settlements, has then paid the green groups? legal fees.

Sue-and-settle lawsuits with like-minded groups as a way to advance common goals aren?t new. The practice dates back to the Carter administration. But EPA?s recent spate of agreements that have major environmental and economic consequences have come as part of a broader flexing of executive authority, particularly on the issue of climate change. Although Congress remains unlikely to act on the issue, the president vows to use what power he has to address a problem he sees as urgent.

The EPA cases are spurring a big backlash from industry and from Republicans on Capitol Hill. In May, the U.S. Chamber of Commerce released a report (?Sue and Settle: Regulating Behind Closed Doors?) slamming the practice. Last week, the GOP-controlled House Judiciary Committee held an investigative hearing, calling the report?s author, William Kovacs, the U.S. chamber?s senior vice president of environmental regulation, as a star witness. Kovacs told Congress the sue-and-settle process gives outside groups an outsized, backdoor role in driving the government regulatory agenda. They turn an independent agency into ?an actor subservient to the binding terms of settlement agreements,? Kovacs said. House Republicans have introduced legislation to curb the practice.

Environmental groups contend they are merely forcing the administration to follow the letter of the law when it?s politically inconvenient to do so. Outside groups can?t sue EPA to create or issue new regulations; most of the sue-and-settle cases compel the agency to issue regulations for which it has already missed a statutory deadline. But in the settlement of the climate-change suit, advocates forced EPA to regulate greenhouse gases from oil refineries, which it might not have done on its own, according to both industry and green groups. ?There were just as many sue-and-settlements in other administrations. What has increased is the significance,? says Roger Martella, EPA?s general counsel during the George W. Bush administration. ?These are economywide mega-rule-makings ... as opposed to small settlements impacting only a limited issue.?

These cases are ?very powerful, because early Congresses saw the wisdom of giving ordinary citizens the ability to enforce the law, even if administrations were unwilling to,? says John Walke, a lawyer with the Natural Resources Defense Council who has worked on many of the recent sue-and-settle agreements. ?They?re occupying a political vacuum ? a space created by an utterly dysfunctional Congress.? Walke says that when an agency agrees to settle a lawsuit with an outside group rather than fighting it, ?there?s a meeting of the minds as to what the law requires.?

EPA contends that by quickly settling the lawsuits instead of fighting them, it saves money. According to data the agency provided to National Journal, in instances where EPA paid legal costs between June 1, 2010, and Sept. 29, 2012, the average fees in cases it settled came to $42,000. The average fees in cases where the agency litigated and lost, or partially lost, came to $176,000. ?If there?s a deadline required by the Clean Air Act and a lawsuit that poses a litigation risk, there?s value to the public and the government in settling out of court,? says an EPA official who spoke on condition of anonymity. ?A settlement can save taxpayers a lot of money.?

Ironically, the one point on which all sides?environmentalists, business interests, and EPA?agree is that they?d prefer to see environmental policy move through Congress rather than through court filings or the backrooms of an executive agency. But as long as Capitol Hill remains gridlocked, expect recourse to come from the legal system.

Source: http://news.yahoo.com/green-groups-epa-issue-rules-124617201.html

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